Europe and Southeast Asia are the only regions in the world to have adopted comprehensive legally binding anti-trafficking conventions: the Council of Europe Convention on Action against Trafficking in Human Beings (CoE Trafficking Convention), adopted in 2005, and the ASEAN Convention Against Trafficking in Persons, Especially Women and Children (ASEAN Trafficking Convention), adopted in 2015. Comparative analyses of these two anti-trafficking frameworks, with a view to exploring avenues and obstacles for collaboration between the two regional organisations in addressing this global phenomenon are lacking. This study seeks to bridge this gap by analysing the anti-trafficking frameworks and developments in the CoE and ASEAN to be used by experts, policy makers and practitioners.